The fact that women’s reproductive lifespans are finite affects many personal decisions and is accompanied by postmenopausal side effects. Expansion of the reproductive lifespan could therefore have many benefits. Findings from Zhang and colleagues indicate that manipulation of BIN2 extends the reproductive lifespan of female mice, and hold promise for therapeutic development.
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References
Duncan, F. E. et al. Mol. Hum. Reprod. 26, 797–800 (2020).
Zhu, F. Y. et al. Nat. Aging https://doi.org/10.1038/s43587-021-00133-4 (2021).
Chrienova, Z., Nepovimova, E. & Kuca, K. J. Enzyme Inhib. Med. Chem. 36, 1679–1693 (2021).
Blagosklonny, M. V. Aging 11, 8048–8067 (2019).
Reddy, P. et al. Science 319, 611–613 (2008).
Zhao, H. et al. Antioxid. Redox Signal. 30, 542–559 (2019).
Koyama, H., Wada, T., Nishizawa, Y., Iwanaga, T. & Aoki, Y. Cancer 39, 1403–1409 (1977).
Miller, J. J. III, Williams, G. F. & Leissring, J. C. Am. J. Med. 50, 530–535
Ruth, K. S. et al. Nature 596, 393–397 (2021).
Findlay, J. K., Hutt, K. J., Hickey, M. & Anderson, R. A. Biol. Reprod. 93, 111 (2015).
Tharp, M. E., Malki, S. & Bortvin, A. Nat. Commun. 11, 330 (2020).
Hawkes, K., O’Connell, J. F., Jones, N. G., Alvarez, H. & Charnov, E. L. Proc. Natl Acad. Sci. USA 95, 1336–1339 (1998).
Bravo Núñez, M. A., Sabbarini, I. M., Eide, L. E., Unckless, R. L. & Zanders, S. E. eLife 9, e57936 (2020).
Zanders, S. E. & Unckless, R. L. Curr. Biol. 29, R512–R520 (2019).
Gulbranson, C. & Garrison, J. The Unspoken Truth. Reproductive Longevity and Equality Affects Us All (BIA-ECHO Foundation and Global Consortium for Reproductive Health and Longevity, 2020).
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Schindler, K. Inhibition of BIN2 extends reproductive lifespan. Nat Aging 1, 977–979 (2021). https://doi.org/10.1038/s43587-021-00132-5
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DOI: https://doi.org/10.1038/s43587-021-00132-5