Pancreatic cancer liver metastases show high levels of immunosuppressive macrophages, which promote tumor growth. We found that blocking the efferocytosis pathway during early-stage metastasis in a mouse model inhibited the development of immunosuppressive activity in monocyte-derived macrophages, which restored T cell activation and reduced the metastatic tumor burden.
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References
Hosein, A. N. et al. Translational advances in pancreatic ductal adenocarcinoma therapy. Nat. Cancer 3, 272–286 (2022). A review article that discusses current advances in targeted therapies in PDAC.
DeNardo, D. G. & Ruffell, B. Macrophages as regulators of tumour immunity and immunotherapy. Nat. Rev. Immunol. 19, 369–382 (2019). Areview article that discusses the biology and clinical targeting of macrophages in tumors.
Grzywa, T. M. et al. Myeloid cell-derived arginase in cancer immune response. Front. Immunol. 11, 938 (2020). A review article that discusses the role of arginase-1 in cancer.
Scott, R. S. et al. Phagocytosis and clearance of apoptotic cells is mediated by MER. Nature 411, 207–211 (2001). An article that reports the function of Mer during efferocytosis.
Simon, M. J. et al. Lysosomal functions of progranulin and implications for treatment of frontotemporal dementia. Trends Cell Biol. 33, 324–339 (2023). A review article that discusses the function of progranulin in lysosomes.
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This is a summary of: Astuti, Y. et al. Efferocytosis reprograms the tumor microenvironment to promote pancreatic cancer liver metastasis. Nat. Cancer https://doi.org/10.1038/s43018-024-00731-2 (2024).
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Clearance of dead cells by efferocytosis promotes liver metastasis in pancreatic cancer. Nat Cancer (2024). https://doi.org/10.1038/s43018-024-00732-1
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DOI: https://doi.org/10.1038/s43018-024-00732-1
