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Cancer genomics

Redistribution of mutation risk in cancer

A genome-wide study of variation in mutation rates in human cancer reveals robust patterns of change in mutation risk across chromosomal domains and with varying replication times.

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Fig. 1: Intertwined effects of chromatin trans-organization.

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Correspondence to Subhajyoti De.

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Hu, X., De, S. Redistribution of mutation risk in cancer. Nat Cancer 5, 216–217 (2024). https://doi.org/10.1038/s43018-024-00728-x

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