As we age, organs undergo architectural and functional changes that deeply affect the fate of disseminated tumor cells (DTCs). A study now adds further complexity to this picture by revealing a role for the age-induced, fibrosis-associated factor PDGF-C in enabling ER+ DTCs to reawaken in aging lungs and thrive as overt metastasis.
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Drapela, S., Gomes, A.P. The aging lung reawakens dormant tumor cells. Nat Cancer 4, 442–443 (2023). https://doi.org/10.1038/s43018-023-00537-8
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DOI: https://doi.org/10.1038/s43018-023-00537-8