Clinical utility of T cell engagers (TCEs) in cancer immunotherapy for solid tumors is hampered by on-target off-tumor activity and dose-limiting adverse events. A study now proposes a solution to tackle these challenges through the design and preclinical characterization of extended half-life TCEs that are conditionally activated in the tumor microenvironment.
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Silver, A.B., Wang, J. & Spangler, J.B. Masking T cell engagers mitigates on-target off-tumor activity. Nat Cancer 4, 439–441 (2023). https://doi.org/10.1038/s43018-023-00529-8
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DOI: https://doi.org/10.1038/s43018-023-00529-8