High-fat diet and the secretome of breast tumors prime distant organs for metastasis formation. During lung priming, alveolar type II cells increase the release of palmitate, which is oxidized to acetyl-CoA by metastasizing breast cancer cells, where the increased acetylation of the NF-κB subunit p65 activates a pro-metastatic transcriptional program.
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References
Fares, J., Fares, M. Y., Khachfe, H. H., Salhab, H. A. & Fares, Y. Molecular principles of metastasis: a hallmark of cancer revisited. Signal Transduct. Target. Ther. 5, 28 (2020). A review article that describes recent advancements in the study of the biological mechanisms of the metastatic process.
Wortzel, I., Dror, S., Kenific, C. M. & Lyden, D. Exosome-mediated metastasis: communication from a istance. Dev. Cell 49, 347–360 (2019). A review article that explains changes in distant organs during the formation of the pre-metastatic niche.
Bergers, G. & Fendt, S. M. The metabolism of cancer cells during metastasis. Nat. Rev. Cancer 21, 162 (2021). A review article that presents evidence supporting the presence of dynamic changes in the metabolism of metastasizing cells.
Altea‐Manzano, P., Cuadros, A. M., Broadfield, L. A. & Fendt, S. Nutrient metabolism and cancer in the in vivo context: a metabolic game of give and take. EMBO Rep. 21, e50635 (2020). A review article that explains the different nutrient networks that tumor cells are capable of using during the different stages of cancer development.
Locasale, J. W. Diet and exercise in cancer metabolism. Cancer Discov. 12, 2249–2257 (2022). A review article that explains the influence of diet in tumor metabolism and discusses mechanisms of diet and exercise as cancer therapies.
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This is a summary of: Altea-Manzano, P. et al. A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-κB signaling. Nat. Cancer https://doi.org/10.1038/s43018-023-00513-2 (2023).
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Palmitate oxidation drives a pro-metastatic post-translational modification. Nat Cancer 4, 315–316 (2023). https://doi.org/10.1038/s43018-023-00514-1
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DOI: https://doi.org/10.1038/s43018-023-00514-1
