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Cancer biomarkers

HDAC6 score: to treat or not to treat?

Nature Cancer volume 4, pages 156–158 (2023)Cite this article

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Developing approaches to identify patients who may benefit from specific treatments is an important area of research. A study now defines an HDAC6 score to predict the response of patients with breast cancer to the HDAC6 inhibitor ricolinostat and characterizes its anti-tumor effects with preclinical mechanistic work and a phase 1b clinical trial.

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Fig. 1: High HDAC6 score reveals sensitivity to HDCA6 inhibition.

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Authors and Affiliations

  1. Division of Cancer Epigenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany

    Joschka Hey, Maria Llamazares Prada & Christoph Plass

  2. Cancer-Transitional Research and Exchange Program, German-Israeli Helmholtz Research School in Cancer Biology, Heidelberg, Germany

    Joschka Hey & Christoph Plass

  3. Translational Lung Research Center (TLRC), member of the German Center for Lung Research (DZL), Heidelberg, Germany

    Joschka Hey, Maria Llamazares Prada & Christoph Plass

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  1. Joschka Hey
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  2. Maria Llamazares Prada
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  3. Christoph Plass
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Correspondence to Christoph Plass.

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Hey, J., Llamazares Prada, M. & Plass, C. HDAC6 score: to treat or not to treat?. Nat Cancer 4, 156–158 (2023). https://doi.org/10.1038/s43018-022-00494-8

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