Immunotherapy has shown great promise in the treatment of patients with advanced non-small-cell lung cancer. We show that integration of data collected during diagnostic clinical work-up with machine learning has the potential to improve predictions of response to immunotherapy and to identify the patients most likely to benefit.
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References
Bera, K. et al. Predicting cancer outcomes with radiomics and artificial intelligence in radiology. Nat. Rev. Clin. Oncol. 19, 132–146 (2022). A perspective article describing the opportunities for using artificial intelligence in radiological imaging.
Echle, A. et al. Deep learning in cancer pathology: a new generation of clinical biomarkers. Br. J. Cancer 124, 686–696 (2021). A review article describing deep learning applications to cancer histopathology.
Boehm, K. M. et al. Harnessing multimodal data integration to advance precision oncology. Nat. Rev. Cancer 22, 114–126 (2022). A perspective article offering opinions on integrating modalities with machine learning methods.
Ilse, M., Tomczak, J. M. & Welling, M. Attention-based deep multiple instance learning. Proceedings of the 35th International Conference on Machine Learning. Proc. Mach. Learn. Res. 80, 2127–2136 (2018). This paper describes the deep learning model that inspired our approach.
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This is a summary of: Vanguri, R. S. et al. Multimodal integration of radiology, pathology and genomics for prediction of response to PD-(L)1 blockade in patients with non-small cell lung cancer. Nat. Cancer https://doi.org/10.1038/s43018-022-00416-8 (2022).
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Multimodal data integration improves immunotherapy response prediction. Nat Cancer 3, 1149–1150 (2022). https://doi.org/10.1038/s43018-022-00417-7
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DOI: https://doi.org/10.1038/s43018-022-00417-7