Shedding light on epigenetic mechanisms controlling anti-tumor immune responses, a new study shows that the tumor-intrinsic ring finger protein 2 (RNF2), the catalytic subunit of Polycomb repressor complex 1 (PRC1), acts as a negative regulator of a collaborative NK and CD4+ T cell anti-tumor immune response against breast cancer.
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Peeters, J.G.C., DuPage, M. A PRC1–RNF2 knockout punch for cancer. Nat Cancer 2, 996–997 (2021). https://doi.org/10.1038/s43018-021-00270-0
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DOI: https://doi.org/10.1038/s43018-021-00270-0