Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

IMMUNOTHERAPY

Immunoradiotherapy goes club(bing)

Nature Cancer volume 2, pages 871–872 (2021)Cite this article

Subjects

Combining radiation and immune checkpoint blockade is a promising treatment strategy, yet the mechanisms and optimal dosing strategies are not well known. A new study finds that a specific radiation dose can activate secretory club cells to promote the anti-tumor effects of radiotherapy combined with immunotherapy in NSCLC.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Schematic of radiotherapy (RT) and anti-PD-1 immunotherapy interactions in mouse lung cancer models from the work of Ban et al.

References

  1. Antonia, S. J. et al. N. Engl. J. Med. 379, 2342–2350 (2018).

    Article  CAS  PubMed  Google Scholar 

  2. Bradley, J. D. et al. Lancet Oncol. 16, 187–199 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Weichselbaum, R. R., Liang, H., Deng, L. & Fu, Y. X. Nat. Rev. Clin. Oncol. 14, 365–379 (2017).

    Article  CAS  PubMed  Google Scholar 

  4. Arina, A., Gutiontov, S. I. & Weichselbaum, R. R. Clin. Cancer Res. 26, 2777–2782 (2020).

    Article  CAS  PubMed  Google Scholar 

  5. Vanpouille-Box, C. et al. Nat. Commun. 8, 15618 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Kelly, R. J. et al. N. Engl. J. Med. 384, 1191–1203 (2021).

    Article  CAS  PubMed  Google Scholar 

  7. Lee, N. Y. et al. Lancet Oncol. 22, 450–462 (2021).

    Article  CAS  PubMed  Google Scholar 

  8. Bourhis, J. S. et al. Ann. Oncol. 31 (suppl. 4), S1142–S1215 (2020).

  9. Luke, J. J. et al. J. Clin. Oncol. 36, 1611–1618 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Turchan, W. T., Pitroda, S. P. & Weichselbaum, R. R. Clin. Cancer Res. https://doi.org/10.1158/1078-0432.CCR-21-0145 (2021).

  11. Ban, Y. et al. Nat. Cancer https://doi.org/10.1038/s43018-021-00245-1 (2021).

    Article  Google Scholar 

  12. Reynolds, S. D. & Malkinson, A. M. Int. J. Biochem. Cell Biol. 42, 1–4 (2010).

    Article  CAS  PubMed  Google Scholar 

  13. Lhuillier, C. et al. J. Clin. Invest. 131, e138740 (2021).

    Article  CAS  PubMed Central  Google Scholar 

  14. Altorki, N. K. et al. Lancet Oncol. 22, 824–835 (2021).

    Article  CAS  PubMed  Google Scholar 

  15. Luke, J. J. et al. Clin. Cancer Res. https://doi.org/10.1158/1078-0432.CCR-20-1790 (2020).

Download references

Author information

Authors and Affiliations

  1. Department of Radiation and Cellular Oncology, The University of Chicago, Chicago, IL, USA

    Ralph R. Weichselbaum & Sean P. Pitroda

  2. Ludwig Center for Metastasis Research, The University of Chicago, Chicago, IL, USA

    Ralph R. Weichselbaum & Sean P. Pitroda

Authors
  1. Ralph R. Weichselbaum
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sean P. Pitroda
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ralph R. Weichselbaum.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Weichselbaum, R.R., Pitroda, S.P. Immunoradiotherapy goes club(bing). Nat Cancer 2, 871–872 (2021). https://doi.org/10.1038/s43018-021-00256-y

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s43018-021-00256-y

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer