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CANCER METABOLISM

Restraining colorectal cancer with αKG

Nature Cancer volume 1, pages 267–269 (2020)Cite this article

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Although many metabolic dependencies of cancer cells are well documented, altered cancer metabolism has not always been considered an active driver of tumorigenesis. Restrictive glutamine availability is now shown to promote colorectal cancer by lowering α-ketoglutarate levels and thereby promoting DNA hypermethylation, Wnt signaling and cellular de-differentiation.

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Fig. 1: Glutamine availability controls tumorigenicity.

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Authors and Affiliations

  1. Institute of Cancer Research, Department of Medicine I, Medical University of Vienna and Comprehensive Cancer Center, Vienna, Austria

    Dana Krauß

  2. Department of Cell Biology and Cancer Science, The Ruth and Bruce Rappaport Faculty of Medicine, Technion–Israel Institute of Technology, Haifa, Israel

    Eyal Gottlieb

Authors
  1. Dana Krauß
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  2. Eyal Gottlieb
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Correspondence to Eyal Gottlieb.

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The authors declare no competing interests.

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Krauß, D., Gottlieb, E. Restraining colorectal cancer with αKG. Nat Cancer 1, 267–269 (2020). https://doi.org/10.1038/s43018-020-0044-4

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