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Targeting CDK4/6 reorganizes chromatin

Nature Cancer volume 2, pages 16–17 (2021)Cite this article

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The diversity of tumor cell responses to cyclin-dependent kinase 4/6 (CDK4/6) inhibition in breast cancer is a question not yet fully addressed. A recent study defines the effects of CDK4/6 inhibition on chromatin organization and shows that remodeling of the cancer cell epigenome mediates some of the key biological effects of these targeted therapy agents.

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Fig. 1: Chromatin landscape changes induced by CDK4/6 inhibition.

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  1. Cancer Genomics and Proteomics Group, Department of Biomedical Sciences, University of Barcelona, Casanova, Barcelona, Spain

    Antoni Hurtado

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  1. Antoni Hurtado
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Correspondence to Antoni Hurtado.

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Hurtado, A. Targeting CDK4/6 reorganizes chromatin. Nat Cancer 2, 16–17 (2021). https://doi.org/10.1038/s43018-020-00164-7

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