The mechanisms that drive cancer cachexia are unclear. Adipocyte activation of GPR81 by high levels of lactate is now shown to drive adipose tissue browning, thermogenesis and a loss of body weight in mouse models of cancer.
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M.D.G. reports consulting or advisory roles with Scorpion Therapeutics; stock or other ownership interests in Faeth Therapeutics; honoraria from Novartis AG, Pfizer Inc., and Scorpion Therapeutics; patents, royalties, and other intellectual property with Weill Cornell Medicine. J.D.S declares no competing interests.
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Sanford, J.D., Goncalves, M.D. A waste product’s unexpected role in wasting. Nat Metab 6, 608–609 (2024). https://doi.org/10.1038/s42255-024-01010-1
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DOI: https://doi.org/10.1038/s42255-024-01010-1