Mitochondrial proteins are frequently acetylated, but most of these modifications are thought to occur non-enzymatically, rather than requiring an acetyltransferase. A new study by Akhtar and colleagues challenges this view by demonstrating that MOF, a well-characterized histone acetyltransferase, bolsters mitochondrial metabolism by acetylating the complex IV assembly factor COX17.
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Acknowledgements
N.M.N. was supported by the National Institutes of Health grant R35GM151130.
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Niemi, N. MOF moves into mitochondria. Nat Metab 5, 1846–1847 (2023). https://doi.org/10.1038/s42255-023-00892-x
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DOI: https://doi.org/10.1038/s42255-023-00892-x