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Cardiovascular disease

Batokine neuregulin 4 promotes atherosclerotic resolution

Nature Metabolism volume 4, pages 1440–1441 (2022)Cite this article

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Adipose tissue is a specialized connective tissue and a major endocrine organ. Brown adipose tissue (BAT) secretes factors that modulate whole-body metabolic homeostasis and can affect distant organs. The discovery that BAT-secreted neuregulin 4 influences atherosclerotic progression opens new opportunities for treating atherosclerosis.

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Fig. 1: Brown adipose tissue-derived NRG4 protects against atherosclerosis via the ERBB4–AKT–NF-κB pathway.

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Acknowledgements

J.K. is supported by Lundbeckfonden (R307-2018-3667); Carlsberg Fonden (CF19-0687); Kræftens Bekæmpelse (R302-A17296); A.P. Møller Fonden (20-L-0317); Novo Nordisk Fonden (#0073440); Riisfort Fonden; and Steno Diabetes Center Aarhus (SDCA).

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Authors and Affiliations

  1. Department of Biomedicine, Aarhus University, Aarhus, Denmark

    Ibrahim AlZaim & Joanna Kalucka

  2. Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark

    Joanna Kalucka

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  1. Ibrahim AlZaim
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  2. Joanna Kalucka
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Correspondence to Joanna Kalucka.

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The authors declare no competing interests.

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AlZaim, I., Kalucka, J. Batokine neuregulin 4 promotes atherosclerotic resolution. Nat Metab 4, 1440–1441 (2022). https://doi.org/10.1038/s42255-022-00669-8

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