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OBESITY

Skeletal muscle inefficiency protects against obesity

Nature Metabolism volume 1, pages 849–850 (2019)Cite this article

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Obesity is the result of an imbalance between caloric intake from the diet and energy expenditure. A new study provides evidence that alterations in calcium transport efficiency in muscle lead to an increased metabolic rate and protect mice against diet-induced obesity.

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Fig. 1: SERCA inefficiency promotes energy expenditure in skeletal muscle.

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Acknowledgements

This work was supported in part by US National Institutes of Health grant R01 DK098240-01 and an American Diabetes Association- Basic Science Research Award (7-13-BS-131) to M.P.

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  1. Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, USA

    Fangfei Li & Muthu Periasamy

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  1. Fangfei Li
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  2. Muthu Periasamy
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Correspondence to Muthu Periasamy.

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The authors declare no competing interests.

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Li, F., Periasamy, M. Skeletal muscle inefficiency protects against obesity. Nat Metab 1, 849–850 (2019). https://doi.org/10.1038/s42255-019-0116-x

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