Fibrosis is characterized by excessive extracellular matrix (ECM) production relative to catabolism. A new study shows that the fuel choice of fibroblasts impacts this balance, with glycolysis promoting ECM synthesis and fatty acid oxidation stimulating ECM degradation.
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Rabinowitz, J.D., Mutlu, G.M. A metabolic strategy to reverse fibrosis?. Nat Metab 1, 12–13 (2019). https://doi.org/10.1038/s42255-018-0013-8
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DOI: https://doi.org/10.1038/s42255-018-0013-8
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