ADP-ribosylation regulates the activity of numerous proteins involved in the DNA damage response and repair. A new study shows that telomeric DNA can be ADP-ribosylated by PARP1, and prompt removal of the ADP-ribose by TARG1 is essential to preserve telomere integrity, unveiling DNA–ADP-ribosylation as a novel player in telomere stability.
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Acknowledgements
F.L. is a Wallenberg Molecular Medicine fellow and receives financial support from the Knut and Alice Wallenberg Foundation (KAW), CancerFonden and Vetenskapsrådet.
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Doksani, Y., Lottersberger, F. The risky business of ADP-ribosylating telomeric DNA. Nat Struct Mol Biol 31, 737–738 (2024). https://doi.org/10.1038/s41594-024-01285-8
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DOI: https://doi.org/10.1038/s41594-024-01285-8
