Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Receptor biology

How to control hunger

Nature Structural & Molecular Biology volume 30, pages 409–411 (2023)Cite this article

Subjects

White adipose tissue secretes the small polypeptide hormone leptin, which controls food intake and satiety. Unlike other metabolic hormones such as insulin and glucagon, leptin does not act on the major metabolic organs liver, muscle, and white adipose tissue, but instead exerts its primary function on the central nervous system.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Leptin-dependent assembly and activation of LepR complex.

References

  1. Friedman, J. M. Nat. Metab. 1, 754–764 (2019).

    Article  CAS  PubMed  Google Scholar 

  2. Zhang, Y. et al. Nature 372, 425–432 (1994).

    Article  CAS  PubMed  Google Scholar 

  3. Halaas, J. L. et al. Science 269, 543–546 (1995).

    Article  CAS  PubMed  Google Scholar 

  4. Pelleymounter, M. A. et al. Science 269, 540–543 (1995).

    Article  CAS  PubMed  Google Scholar 

  5. Myers, M. G., Cowley, M. A. & Münzberg, H. Annu. Rev. Physiol. 70, 537–556 (2008).

    Article  CAS  PubMed  Google Scholar 

  6. Iserentant, H. et al. J. Cell Sci. 118, 2519–2527 (2005).

    Article  CAS  PubMed  Google Scholar 

  7. Peelman, F. et al. J. Biol. Chem. 281, 15496–15504 (2006).

    Article  CAS  PubMed  Google Scholar 

  8. Mancour, L. V. et al. Mol. Cell 48, 655–661 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Moharana, K. et al. Structure 22, 866–877 (2014).

    Article  CAS  PubMed  Google Scholar 

  10. Saxton, R. A. et al. Nat. Commun. https://doi.org/10.1038/s41467-023-37169-6 (2023).

  11. Li, J. et al. Nat. Struct. Mol. Biol. 29, 357–368 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  12. Scapin, G. et al. Nature 556, 122–125 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Li, J., Choi, E., Yu, H. & Bai, X. C. Nat. Commun. 10, 4567 (2019).

  14. Tsirigotaki, A. et al. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-023-00941-9 (2023).

  15. Fei, H. et al. Proc. Natl Acad. Sci. USA 94, 7001–7005 (1997).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

E.C. is supported in part by US National Institutes of Health grants R01DK132361, R35GM142937, P30DK132710, and P30DK063608.

Author information

Authors and Affiliations

  1. Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA

    Albert Hung & Eunhee Choi

Authors
  1. Albert Hung
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Eunhee Choi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Eunhee Choi.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hung, A., Choi, E. How to control hunger. Nat Struct Mol Biol 30, 409–411 (2023). https://doi.org/10.1038/s41594-023-00963-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41594-023-00963-3

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing