A cardinal rule of DNA replication is to prevent any possibility of pre-replication complexes re-loading during S phase, risking genotoxic over-replication. But can this rule be broken in emergency situations to preserve genome integrity?
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Hu, Y. & Stillman, B. Mol. Cell 83, 352–372 (2023).
Brison, O. et al. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-023-00949-1 (2023).
Rhind, N. BioEssays 44, 2200097 (2022).
Hyrien, O., Marheineke, K. & Goldar, A. BioEssay 25, 116–125 (2003).
Kuipers, M. A. et al. J. Cell Biol. 192, 29–41 (2011).
Sasaki, T. et al. Mol. Cell Biol. 26, 1051–1062 (2006).
Emerson, D. J. et al. Nature 606, 812–819 (2022).
Blow, J. J., Ge, X. Q. & Jackson, D. A. Trends Biochem. Sci. 36, 405–414 (2011).
Lemmens, B. et al. Mol. Cell 71, 117–128 (2018).
Mirceta, M., Shum, N., Schmidt, M. H. M. & Pearson, C. E. Front. Genet. 13, 985975 (2022).
Ji, F. et al. Front. Genet. 13, 906957 (2022).
Debatisse, M. & Rosselli, F. Genes Chromosom. Cancer 58, 305–316 (2019).
Shaikh, N. et al. Genome Biol. 23, 223 (2022).
Techer, H., Koundrioukoff, S., Nicolas, A. & Debatisse, M. Nat. Rev. Genet. 18, 535–550 (2017).
Sedlackova, H. et al. Nature 587, 297–302 (2020).
Li, J. et al. Cell 186, 98–111.e21 (2023).
Bartlett, D. A. et al. J. Cell Biol. 220, e202103078 (2021).
Kanemaki, M. T. Curr. Opin. Cell Biol. 74, 29–36 (2022).
Michowski, W. et al. Mol. Cell 78, 459–476.e13 (2020).
Wei, P.-C. et al. Cell 164, 644–655 (2016).
Acknowledgements
I thank B. Kerem for critical reading of this essay. The work in my lab most relevant to this study is funded by US National Institues of Health grant R01CA270335.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing interests.
Rights and permissions
About this article
Cite this article
Gilbert, D.M. Replication licensing during S phase: breaking the law to prevent breaking DNA. Nat Struct Mol Biol 30, 406–408 (2023). https://doi.org/10.1038/s41594-023-00962-4
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41594-023-00962-4