Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Transcriptional regulation

When transcription initiation meets chromatin

Nature Structural & Molecular Biology volume 30, pages 131–133 (2023)Cite this article

Subjects

Gene transcription initiation is a highly regulated process in which Pol II and general transcription factors assemble into a pre-initiation complex. Structural studies of yeast and human initiation complexes shed light on the role of the first nucleosome flanking gene promoters in controlling the transcription machinery.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Schematic summary of the PIC–nucleosome complex assembly.

References

  1. Chen, X. et al. Science 372, eaba8490 (2021).

    Article  CAS  PubMed  Google Scholar 

  2. Chen, X. et al. Science 372, eabg0635 (2021).

    Article  CAS  PubMed  Google Scholar 

  3. Abdella, R. et al. Science 372, 52–56 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Rengachari, S., Schilbach, S., Aibara, S., Dienemann, C. & Cramer, P. Nature 594, 129–133 (2021).

    Article  CAS  PubMed  Google Scholar 

  5. Aibara, S., Schilbach, S. & Cramer, P. Nature 594, 124–128 (2021).

    Article  CAS  PubMed  Google Scholar 

  6. Schilbach, S. et al. Nature 551, 204–209 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Chen, X. et al. Science 378, 62–68 (2022).

    Article  CAS  PubMed  Google Scholar 

  8. Wang, H., Schilbach, S., Ninov, M., Urlaub, H. & Cramer, P. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-022-00865-w (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  9. Schones, D. E. et al. Cell 132, 887–898 (2008).

    Article  CAS  PubMed  Google Scholar 

  10. Struhl, K. Annu. Rev. Biochem. 58, 1051–1077 (1989).

    Article  CAS  PubMed  Google Scholar 

  11. Albert, I. et al. Nature 446, 572–576 (2007).

    Article  CAS  PubMed  Google Scholar 

  12. Fishburn, J., Galburt, E. & Hahn, S. J. Biol. Chem. 291, 13040–13047 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Kornberg, R. D. & Lorch, Y. Mol. Cell 79, 371–375 (2020).

    Article  CAS  PubMed  Google Scholar 

  14. Nagai, S., Davis, R. E., Mattei, P. J., Eagen, K. P. & Kornberg, R. D. Proc. Natl Acad. Sci. USA 114, 1536–1541 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Lu, H. et al. Nature 558, 318–323 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Cramer, P. Nature 573, 45–54 (2019).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France

    Patrick Schultz

  2. CNRS, UMR7104, Illkirch, France

    Patrick Schultz

  3. Inserm, UMR-S 1258, Illkirch, France

    Patrick Schultz

  4. Université de Strasbourg, Illkirch, France

    Patrick Schultz

Authors
  1. Patrick Schultz
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Patrick Schultz.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Schultz, P. When transcription initiation meets chromatin. Nat Struct Mol Biol 30, 131–133 (2023). https://doi.org/10.1038/s41594-022-00916-2

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41594-022-00916-2

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing