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AAA ATPASES

A spiral path to unfolding

Nature Structural & Molecular Biology volume 26, pages 763–765 (2019)Cite this article

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An Author Correction to this article was published on 21 September 2019

This article has been updated

AAA ATPases constitute a large family of molecular chaperones, many of which unfold substrate proteins. Two recent cryo-EM studies of the AAA ATPase Cdc48 capture this enzyme in the midst of protein unfolding and reveal a universal substrate-threading mechanism for ring-shaped ATPases.

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Fig. 1: How Cdc48 unfolds proteins.

Change history

  • 21 September 2019

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Authors and Affiliations

  1. Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA

    Yihong Ye

  2. Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

    Di Xia

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  1. Yihong Ye
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  2. Di Xia
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Correspondence to Yihong Ye or Di Xia.

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Ye, Y., Xia, D. A spiral path to unfolding. Nat Struct Mol Biol 26, 763–765 (2019). https://doi.org/10.1038/s41594-019-0284-0

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