We have developed a framework for the analysis of multi-batch proteome profiling data using isobaric mass tags. Our framework improves quantitative accuracy and increases statistical power by accounting for known sources of variation between batches, thus enabling multiplexed proteome profiling analysis to be performed on large numbers of samples and population cohorts.
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References
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This is a summary of: O’Brien, J. J. et al. A data analysis framework for combining multiple batches increases the power of isobaric proteomics experiments. Nat. Methods https://doi.org/10.1038/s41592-023-02120-6 (2023).
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Increasing the analytic power for multi-batch proteome profiling with isobaric mass tags. Nat Methods 21, 168–169 (2024). https://doi.org/10.1038/s41592-023-02121-5
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DOI: https://doi.org/10.1038/s41592-023-02121-5
