Advancements in methods that enable in vitro culture of mammalian embryos have become an essential way of investigating mammalian early embryonic development and modeling developmental and pregnancy-related disorders. Here, we discuss the recent method development in this space and analyze current challenges and future directions.
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Acknowledgements
This work was supported by the National Key Research and Development Program of China (2022YFA1103100, 2021YFA0805701, 2020YFA0112201 and 2021YFC2700302), the Key Deployment Project of the Chinese Academy of Sciences (ZDBS-ZRKJZ-TLC001) and grants from the NSFC (82192870, 82322026, 32100654 and 82201857).
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X.W., J.Z., Q.L. and H.W. cowrote the manuscript. X.W. and J.Z. composed the figures.
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Wu, X., Zhai, J., Li, Q. et al. The in vitro culture of mammalian embryos. Nat Methods 20, 1855–1858 (2023). https://doi.org/10.1038/s41592-023-02071-y
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DOI: https://doi.org/10.1038/s41592-023-02071-y
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