We deeply characterized the early-life gut virome, which consists mainly of bacteriophages (phages) and the diversity of which greatly exceeds bacterial diversity. The virome was associated with later asthma development, independently of the bacterial hosts of the phages; we further uncovered intriguing interactions with immune genetics.
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References
Stokholm, J. et al. Maturation of the gut microbiome and risk of asthma in childhood. Nat. Commun. 9, 141 (2018). This paper presents the link between the early life gut microbiome and childhood asthma development.
Gogokhia, L. et al. Expansion of bacteriophages is linked to aggravated intestinal inflammation and colitis. Cell Host Microbe 25, 285–299.e8 (2019). This research article reports how bacteriophages may stimulate immune responses via TLR9.
Shah, S. A. et al. Expanding known viral diversity in the healthy infant gut. Nat. Microbiol. 8, 986–998 (2023). This paper describes the viral diversity of infants in the COPSAC2010 cohort.
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This is a summary of: Leal Rodríguez, C. et al. The infant gut virome is associated with preschool asthma risk independently of bacteria. Nat. Med. https://doi.org/10.1038/s41591-023-02685-x (2023).
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Beyond bacteria: early-life gut virome link with childhood asthma development. Nat Med 30, 43–44 (2024). https://doi.org/10.1038/s41591-023-02747-0
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DOI: https://doi.org/10.1038/s41591-023-02747-0
