We find that people with non-suppressible human immunodeficiency virus (HIV) viremia despite antiretroviral therapy (ART) exhibit several distinguishing features. These include expanded CD4+ T cell clones containing HIV proviruses integrated into transcriptionally permissive regions, the presence of certain proviral defects or human leukocyte antigen (HLA)-escape mutations, enhanced survival signatures, and muted interferon and cytotoxic CD8+ T cell responses.
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This is a summary of: Mohammadi, A. et al. Viral and host mediators of non-suppressible HIV-1 viremia. Nat. Med. https://doi.org/10.1038/s41591-023-02611-1 (2023).
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Viral, cellular and immune aspects of non-suppressible HIV-1 viremia. Nat Med 29, 3016–3017 (2023). https://doi.org/10.1038/s41591-023-02688-8
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DOI: https://doi.org/10.1038/s41591-023-02688-8