Pre-symptomatic gene editing in preclinical models of hypertrophic cardiomyopathy shows therapeutic promise; clinical studies are now needed to assess safety and efficacy in humans.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Circular RNA circZFPM2 regulates cardiomyocyte hypertrophy and survival
Basic Research in Cardiology Open Access 19 April 2024
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Marian, A. J. & Braunwald, E. Circ. Res. 121, 749–770 (2017).
Maron, B. J., Maron, M. S. & Semsarian, C. J. Am. Coll. Cardiol. 60, 705–715 (2012).
Wolf, C. M. Cardiovasc. Diagn. Ther. 9, S388–S415 (2019).
Olivotto, I. et al. Lancet 396, 759–769 (2020).
Gillmore, J. D. et al. N. Engl. J. Med. 385, 493–502 (2021).
Uddin, F., Rudin, C. M. & Sen, T. Front. Oncol. 10, 1387 (2020).
Reichart, D. et al. Nat. Med. https://doi.org/10.1038/s41591-022-02176-5 (2022).
Chai, A. C. et al. Nat. Med. https://doi.org/10.1038/s41591-022-02190-7 (2022).
Jeong, Y. K., Song, B. & Bae, S. Mol. Ther. 28, 1938–1952 (2020).
Hakim, C. H. et al. Nat. Commun. 12, 6769 (2021).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing interests.
Rights and permissions
About this article
Cite this article
Strong, A. CRISPR gene-editing therapies for hypertrophic cardiomyopathy. Nat Med 29, 305–306 (2023). https://doi.org/10.1038/s41591-022-02184-5
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41591-022-02184-5
This article is cited by
-
Hypertrophic Cardiomyopathy
Current Heart Failure Reports (2024)
-
Circular RNA circZFPM2 regulates cardiomyocyte hypertrophy and survival
Basic Research in Cardiology (2024)