Quorum-sensing bacteria can deliver a nanobody targeting the ‘don’t eat me’ ligand CD47 to tumors that results in systemic anti-tumor immunity-induced regression in mice.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Yeast-derived nanoparticles remodel the immunosuppressive microenvironment in tumor and tumor-draining lymph nodes to suppress tumor growth
Nature Communications Open Access 10 January 2022
-
The role of the tumor microbe microenvironment in the tumor immune microenvironment: bystander, activator, or inhibitor?
Journal of Experimental & Clinical Cancer Research Open Access 16 October 2021
-
Antiproliferative effects on tumor cells of the synthesized gold nanoparticles against Hep2 liver cancer cell line
Egyptian Liver Journal Open Access 06 March 2020
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Starnes, C. O. Nature 357, 11–12 (1992).
Chowdhury, S. et al. Nat. Med. https://doi.org/10.1038/s41591-019-0498-z (2019).
Ingram, J. R., Schmidt, F. I. & Ploegh, H. L. Annu. Rev. Immunol. 36, 695–715 (2018).
Sockolosky, J. T. et al. Proc. Natl Acad. Sci. USA 113, E2646–E2654 (2016).
Jaiswal, S. et al. Cell 138, 271–285 (2009).
Weiskopf, K. Eur. J. Cancer 76, 100–109 (2017).
Weiskopf, K. et al. Science 341, 88–91 (2013).
Advani, R. et al. N. Engl. J. Med. 379, 1711–1721 (2018).
Ingram, J. R. et al. Proc. Natl Acad. Sci. USA 114, 10184–10189 (2017).
Liu, X. et al. Nat. Med. 21, 1209–1215 (2015).
Xu, M. M. et al. Immunity 47, 363–373.e365 (2017).
Silva, D. A. et al. Nature 565, 186–191 (2019).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Dougan, M., Dougan, S.K. Programmable bacteria as cancer therapy. Nat Med 25, 1030–1031 (2019). https://doi.org/10.1038/s41591-019-0513-4
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41591-019-0513-4
This article is cited by
-
Systemic immune responses to irradiated tumours via the transport of antigens to the tumour periphery by injected flagellate bacteria
Nature Biomedical Engineering (2022)
-
Yeast-derived nanoparticles remodel the immunosuppressive microenvironment in tumor and tumor-draining lymph nodes to suppress tumor growth
Nature Communications (2022)
-
The role of the tumor microbe microenvironment in the tumor immune microenvironment: bystander, activator, or inhibitor?
Journal of Experimental & Clinical Cancer Research (2021)
-
Antiproliferative effects on tumor cells of the synthesized gold nanoparticles against Hep2 liver cancer cell line
Egyptian Liver Journal (2020)