The transient expression of CD61 and its unconventional pairing with CD103 at the immune synapse enhances T cell receptor signaling, improves anti-tumor cytotoxicity and mitigates tumor growth. Clinically, CD61+ tumor infiltrating lymphocytes (TILs) exhibit enhanced effector functions and show limited cellular exhaustion.
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References
Ganesan, A. P. et al. Tissue-resident memory features are linked to the magnitude of cytotoxic T cell responses in human lung cancer. Nat. Immunol. 18, 940–950 (2017). This paper reports lung tumors with enriched tissue-resident memory T cell transcriptomes, including those that express CD103, which are predictive of better survival outcome.
Malik, B. T. et al. Resident memory T cells in the skin mediate durable immunity to melanoma. Sci. Immunol. 2, eaam6346 (2017). This paper shows that melanoma antigen-specific tissue resident memory T cells require CD103 expression to establish tissue-residency in skin, and for protection against melanoma rechallenge.
Abd Hamid, M. et al. Self-maintaining CD1033+ cancer-specific T cells are highly energetic with rapid cytotoxic and effector responses. Cancer. Immunol. Res. 8, 203–216 (2020). This paper reports rapid instances of cancer cell killing by CD103. cancer-specific T cells, attributed to their increased metabolism.
Hynes, R. O. Integrins: bidirectional, allosteric signalling machines. Cell 110, 673–687 (2002). A review article that highlights the fundamentals of integrins, their signaling and known pairing combinations.
Moulder, K., Roberts, K., Shevach, E. M. & Coligan, J. E. The mouse vitronectin receptor is a T cell activation antigen. J. Exp. Med. 173, 343–347 (1991). This paper reports the expression of CD61 (and its pairing with CD51) on mouse T cells.
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This is a summary of: Hamid, M. H. B. A. et al. Unconventional human CD61 pairing with CD103 promotes TCR signaling and antigen-specific T cell cytotoxicity. Nat. Immunol. https://doi.org/10.1038/s41590-024-01802-3 (2024).
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Transient synaptic CD61 pairing with CD103 increases the cytotoxicity of antigen-specific T cells. Nat Immunol 25, 739–740 (2024). https://doi.org/10.1038/s41590-024-01829-6
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DOI: https://doi.org/10.1038/s41590-024-01829-6
