Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

T cells

Virtual memory is a big hairy deal

CD8+ virtual memory T cells have been studied mainly for their antimicrobial functions but it seems that their descendants can contribute to inflammation and hair loss in the context of alopecia areata.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: TVM cells in alopecia areata.

References

  1. Haluszczak, C. et al. J. Exp. Med. 206, 435–448 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Seok, J. et al. Nat. Immunol. https://doi.org/10.1038/s41590-023-01547-5 (2023).

    Article  PubMed  Google Scholar 

  3. White, J. T., Cross, E. W. & Kedl, R. M. Nat. Rev. Immunol. 17, 391–400 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Akue, A. D., Lee, J. Y. & Jameson, S. C. J. Immunol. 188, 2516–2523 (2012).

    Article  CAS  PubMed  Google Scholar 

  5. Smith, N. L. et al. Cell 174, 117–130 (2018).

    Article  CAS  PubMed  Google Scholar 

  6. Rudd, B. D. et al. Proc. Natl Acad. Sci. USA 108, 13694–13699 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Chu, T. et al. Cell Rep. 3, 701–708 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. White, J. T. et al. Nat. Commun. 7, 11291 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Lee, H., Jeong, S. & Shin, E. C. Nat. Immunol. 23, 13–22 (2022).

    Article  CAS  PubMed  Google Scholar 

  10. Miller, C. H. et al. Nat. Immunol. 21, 567–577 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Ortolan, L. S. et al. J. Allergy Clin. Immunol. 144, 1731–1734 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  12. Celik, S. D. & Ates, O. J. Clin. Lab. Anal. 32, e22386 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Ross M. Kedl or Stephen C. Jameson.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kedl, R.M., Jameson, S.C. Virtual memory is a big hairy deal. Nat Immunol 24, 1215–1216 (2023). https://doi.org/10.1038/s41590-023-01564-4

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41590-023-01564-4

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing