New work from Udeochu, Amin, Huang, and colleagues provides mechanistic insights into how the tau protein engages the cGAS–STING pathway to elicit antiviral responses in Alzheimer’s disease. This signaling axis diminishes the MEF2C transcriptional network in neurons critical for maintaining cognitive function.
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References
Keren-Shaul, H. et al. Cell 169, 1276–1290.e1217 (2017).
Da Mesquita, S. et al. Sci. Adv. 7, eabe4601 (2021).
Roy, E. R. et al. Immunity 55, 879–894.e876 (2022).
Decout, A., Katz, J. D., Venkatraman, S. & Ablasser, A. Nat. Rev. Immunol. 21, 548–569 (2021).
Baruch, K. et al. Science 346, 89–93 (2014).
Udeochu, J. C. Nat. Neurosci. https://doi.org/10.1038/s41593-023-01315-6 (2023).
Yu, C.-H. et al. Cell 183, 636–649 (2020).
Barker, S. J. et al. Sci. Transl. Med. 13 (2021).
Deczkowska, A. et al. Nat. Commun. 8, 717 (2017).
Guo, C. et al. Cell Rep. 23, 2874–2880 (2018).
Dulken, B. W. et al. Nature 571, 205–210 (2019).
Salvador, A. F., de Lima, K. A. & Kipnis, J. Nat. Rev. Immunol. 21, 526–541 (2021).
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Salvador, A.F.M., Kipnis, J. Resilient brains run out of (c)GAS. Nat Immunol 24, 741–742 (2023). https://doi.org/10.1038/s41590-023-01485-2
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DOI: https://doi.org/10.1038/s41590-023-01485-2
