Aging is commonly associated with the loss of cognitive capacity driven by the degeneration of the brain. New research strengthens the links between CD8+ T cells and interferon-γ production in the brain, and neurodegeneration.
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References
Kaya, T. et al. Nat. Neurosci. 25, 1446–1457 (2022).
Smolders, J. et al. Nat. Commun. 9, 4593 (2018).
Holden, S. S. et al. Science 373, eabj2685 (2021).
Dulken, B. W. et al. Nature 571, 205–210 (2019).
Kirby, L. et al. Nat. Commun. 10, 3887 (2019).
Di Liberto, G. et al. Cell 175, 458–471.e19 (2018).
Hottinger, A. F. Curr. Opin. Neurol. 29, 806–812 (2016).
Dorman, L. C. et al. Preprint at bioRxiv https://doi.org/10.1101/2021.04.29.441889 (2022).
Roy, E. R. et al. J. Clin. Invest. 130, 1912–1930 (2020).
Frieser, D. et al. Sci. Transl. Med. 14, eabl6157 (2022).
Yshii, L. et al. Nat. Immunol. 23, 878–891 (2022).
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The authors are potential financial beneficiaries of patents covering the use of regulatory T cells in neurodegeneration, which are unrelated to the discussed work.
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Liston, A., Yshii, L. T cells drive aging of the brain. Nat Immunol 24, 12–13 (2023). https://doi.org/10.1038/s41590-022-01390-0
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DOI: https://doi.org/10.1038/s41590-022-01390-0
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