Diverse inflammasome stimuli recruit NLRP3 to dysfunctional endosomes via interactions with lipids that accumulate in excess on these organelles. Excess lipid detection may be a common principle that explains NLRP3 function in health and disease.
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Acknowledgements
This work was supported by National Institutes of Health (NIH) grants AI133524, AI093589, AI116550 and P30DK34854.
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J.C.K. consults and holds equity in Corner Therapeutics, Larkspur Biosciences and Neumora Therapeutics. None of these relationships influenced this work.
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Kagan, J.C. Excess lipids on endosomes dictate NLRP3 localization and inflammasome activation. Nat Immunol 24, 3–4 (2023). https://doi.org/10.1038/s41590-022-01364-2
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DOI: https://doi.org/10.1038/s41590-022-01364-2
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