Small molecules and drugs are not homogenously distributed across cells, and are instead enriched in distinct subcellular compartments and membraneless biomolecular condensates. A new study lays out the path to identifying chemical features or ‘rationales’ that confer condensate-selective partitioning of small molecules.
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Ansari, A.Z. In search of chemical rationales. Nat Chem Biol 20, 264–265 (2024). https://doi.org/10.1038/s41589-023-01488-y
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DOI: https://doi.org/10.1038/s41589-023-01488-y
