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Covalent ligand

Flipping the polarity switch

Nature Chemical Biology volume 19, pages 1292–1293 (2023)Cite this article

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A new platform for screening nucleophilic-fragment-based covalent ligands enables the identification and targeting of ligandable sulfenic acid sites, setting the stage for exploration of nucleophile-directed probe and drug development.

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Fig. 1: Exploring nucleophilic-fragment-based covalent ligand screening.

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  1. Department of Chemistry, Boston College, Chestnut Hill, MA, USA

    Daniel W. Bak

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  1. Daniel W. Bak
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Correspondence to Daniel W. Bak.

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The author declares no competing interests.

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Bak, D.W. Flipping the polarity switch. Nat Chem Biol 19, 1292–1293 (2023). https://doi.org/10.1038/s41589-023-01347-w

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