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TARGETED PROTEIN STABILIZATION

DUB be good to me

Nature Chemical Biology volume 18, pages 358–359 (2022)Cite this article

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Induced proximity is reshaping drug discovery. A new study debuts deubiquitinase-targeting chimeras (DUBTACs), small bifunctional molecules that co-opt a deubiquitinase to stabilize a target protein.

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Fig. 1: How DUBTACs work.

References

  1. Gerry, C. J. & Schreiber, S. L. Nat. Chem. Biol. 16, 369–378 (2020).

    Article  CAS  Google Scholar 

  2. Mullard, A. Nat. Rev. Drug Discov. 20, 247–250 (2021).

    Article  CAS  Google Scholar 

  3. Modell, A. E., Lai, S., Nguyen, T. M. & Choudhary, A. Cell Chem. Biol. 28, 1081–1089 (2021).

    Article  CAS  Google Scholar 

  4. Henning, N. J. et al. Nat. Chem. Biol. https://doi.org/10.1038/10.1038/s41589-022-00971-2 (2022).

    Article  PubMed  Google Scholar 

  5. Schauer, N. J., Magin, R. S., Liu, X., Doherty, L. M. & Buhrlage, S. J. J. Med. Chem. 63, 2731–2750 (2020).

    Article  CAS  Google Scholar 

  6. Backus, K. M. et al. Nature 534, 570–574 (2016).

    Article  CAS  Google Scholar 

  7. Kanner, S. A., Shuja, Z., Choudhury, P., Jain, A. & Colecraft, H. M. Nat. Methods 17, 1245–1253 (2020).

    Article  CAS  Google Scholar 

  8. Wertz, I. E. & Wang, X. Cell Chem. Biol. 26, 156–177 (2019).

    Article  CAS  Google Scholar 

  9. Imaide, S. et al. Nat. Chem. Biol. 17, 1157–1167 (2021).

    Article  CAS  Google Scholar 

  10. Yau, R. & Rape, M. Nat. Cell Biol. 18, 579–586 (2016).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, Dundee, UK

    Xingui Liu & Alessio Ciulli

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  1. Xingui Liu
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  2. Alessio Ciulli
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Correspondence to Alessio Ciulli.

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Competing interests

A.C. is a scientific founder, shareholder and advisor of Amphista Therapeutics, a company that is developing targeted protein degradation therapeutic platforms. The Ciulli laboratory receives or has received sponsored research support from Almirall, Amgen, Amphista Therapeutics, Boehringer Ingelheim, Eisai, Nurix Therapeutics and Ono Pharmaceutical.

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Liu, X., Ciulli, A. DUB be good to me. Nat Chem Biol 18, 358–359 (2022). https://doi.org/10.1038/s41589-022-00978-9

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