Just how chaperones clear protein aggregates is a notoriously impenetrable problem. A new study now shows how single-molecule movies of Hsp104 and Hsp70 chaperones acting on amyloid fibers are the key to revealing their underlying cooperation in time and space.
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Tans, S.J. Picturing protein disaggregation. Nat Chem Biol 18, 240–241 (2022). https://doi.org/10.1038/s41589-022-00977-w
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DOI: https://doi.org/10.1038/s41589-022-00977-w
