Genetic code expansion is emerging as a promising strategy to precisely regulate protein expression. A new study engineered cells that enabled noncanonical-amino-acid-triggered insulin expression to rapidly regulate blood glucose levels in a diabetic mouse model.
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References
Vargason, A. M., Anselmo, A. C. & Mitragotri, S. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-021-00698-w (2021).
Kitada, T., Diandreth, B., Teague, B. & Weiss, R. Science 359, 651–651 (2018).
Chen, C. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-021-00899-z (2021).
Bakh, N. A. et al. Nat. Chem. 9, 937–944 (2017).
Wang, J. et al. Adv. Mater. 32, 1902004 (2020).
Mansouri, M., Strittmatter, T. & Fussenegger, M. Adv. Sci. 6, 1800952 (2018).
Wang, L., Brock, A., Herberich, B. & Schultz, P. G. Science 292, 498–500 (2001).
Huang, Y. J. & Liu, T. Synth. Syst. Biotechnol. 3, 150–158 (2018).
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Z.G. is the co-founder of Zenomics, Zencapsule, ZCapsule, and Wskin.
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Yu, J., Zhang, Y. & Gu, Z. Treating diabetes with ‘cookies’. Nat Chem Biol 18, 3–4 (2022). https://doi.org/10.1038/s41589-021-00916-1
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DOI: https://doi.org/10.1038/s41589-021-00916-1