A new study reveals that, in addition to its longstanding role in recruiting proteins to the proteasome, ubiquitination can also induce a structural destabilization that allows the target protein to be efficiently unraveled for degradation.
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Roberts, C.G., Pruneda, J.N. Unraveling proteasome engagement. Nat Chem Biol 16, 813–815 (2020). https://doi.org/10.1038/s41589-020-0573-2
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DOI: https://doi.org/10.1038/s41589-020-0573-2