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Chromatin biology

RNA polymerase II promoter-proximal pausing promotes BAF chromatin binding and remodeling

Nature Genetics volume 56, pages 19–20 (2024)Cite this article

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New research reports that paused RNA polymerase II (RNAPII) enhances the targeting and activity of BAF chromatin remodelers. These findings suggest a new paradigm for understanding how the collaborative action of chromatin remodelers and the transcriptional machinery govern cell-type-specific chromatin accessibility.

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Fig. 1: Interplay of BAF, RNAPII and transcription factors in NDR establishment.

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Authors and Affiliations

  1. Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA

    Brent Y. Chick & Diana C. Hargreaves

  2. Biological Sciences Graduate Program, University of California at San Diego, La Jolla, CA, USA

    Brent Y. Chick

Authors
  1. Brent Y. Chick
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  2. Diana C. Hargreaves
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Correspondence to Diana C. Hargreaves.

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The authors declare no competing interests.

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Chick, B.Y., Hargreaves, D.C. RNA polymerase II promoter-proximal pausing promotes BAF chromatin binding and remodeling. Nat Genet 56, 19–20 (2024). https://doi.org/10.1038/s41588-023-01628-z

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