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New ingredients for old recipes

Nature Genetics volume 55, pages 2023–2024 (2023)Cite this article

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The pancreas is an essential organ present in all vertebrates, and human pancreatic agenesis is an extremely rare disorder of largely unknown genetic determinants. A study now demonstrates that a primate-specific regulatory network controlled by the KRAB zinc-finger protein ZNF808 is essential for pancreas development.

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Fig. 1: ZNF808 mutation leads to pancreatic agenesis.

References

  1. Chuong, E. B., Elde, N. C. & Feschotte, C. Nat. Rev. Genet. 18, 71–86 (2017).

    Article  CAS  PubMed  Google Scholar 

  2. Cordaux, R. & Batzer, M. A. Nat. Rev. Genet. 10, 691–703 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. McClintock, B. Cold Spring Harb. Symp. Quant. Biol. 21, 197–216 (1956).

    Article  CAS  PubMed  Google Scholar 

  4. Andrews, G. et al. Science 380, eabn7930 (2023).

    Article  CAS  PubMed  Google Scholar 

  5. Imbeault, M., Helleboid, P.-Y. & Trono, D. Nature 543, 550–554 (2017).

    Article  CAS  PubMed  Google Scholar 

  6. Rosspopoff, O. & Trono, D. Trends Genet. 39, 844–857 (2023).

    Article  CAS  PubMed  Google Scholar 

  7. Pontis, J. et al. Cell Stem Cell 24, 724–735.e5 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Turelli, P. et al. Sci. Adv. 6, eaba3200 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. De Franco, E. et al. Nat. Genet. https://doi.org/10.1038/s41588-023-01565-x (2023).

    Article  PubMed  Google Scholar 

  10. Dassaye, R., Naidoo, S. & Cerf, M. E. Islets 8, 13–34 (2016).

    Article  CAS  PubMed  Google Scholar 

  11. Ecco, G., Imbeault, M. & Trono, D. Development 144, 2719–2729 (2017).

    Article  CAS  PubMed  Google Scholar 

  12. Tachmatzidi, E. C., Galanopoulou, O. & Talianidis, I. Cells 10, 2026 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Rowe, H. M. et al. Nature 463, 237–240 (2010).

    Article  CAS  PubMed  Google Scholar 

  14. Pontis, J. et al. Nat. Commun. 13, 7178 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Takahashi, N. et al. Genes Dev. 33, 49–54 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Johansson, P. A. et al. Cell Stem Cell 29, 52–69 (2022).

    Article  CAS  PubMed  Google Scholar 

Download references

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Author notes

  1. These authors contributed equally: Olga Rosspopoff, Filipe Martins.

Authors and Affiliations

  1. School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

    Olga Rosspopoff, Filipe Martins & Didier Trono

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  1. Olga Rosspopoff
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  2. Filipe Martins
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  3. Didier Trono
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Correspondence to Didier Trono.

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Rosspopoff, O., Martins, F. & Trono, D. New ingredients for old recipes. Nat Genet 55, 2023–2024 (2023). https://doi.org/10.1038/s41588-023-01591-9

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