Current risk assessment and treatment strategies for venous thromboembolism (VTE) consider genetic factors only in a limited way. New work shows a more pervasive role of common variants in VTE risk, inspiring genetic predictors that surpass and complement individual clinical risk factors and monogenic thrombophilia testing.
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G.P. has received consulting fees from Illumina, Bayer and Lifelabs. M.C. has received consulting fees from Bayer and Lifelabs.
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Chong, M., Paré, G. Identifying individuals at extreme risk of venous thromboembolism using polygenic risk scores. Nat Genet 55, 358–360 (2023). https://doi.org/10.1038/s41588-023-01330-0
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DOI: https://doi.org/10.1038/s41588-023-01330-0