A new study highlights a strategy to link SNPs implicated in human complex traits and diseases with probable causal genes. This method prioritizes genes for functional characterization and helps address questions about the architecture of human phenotypes.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
eQTL colocalization analysis highlights novel susceptibility genes in Autism Spectrum Disorders (ASD)
Translational Psychiatry Open Access 31 October 2023
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Buniello, A. et al. Nucleic Acids Res. 47, D1005–D1012 (2019).
Gazal, S. et al. Nat. Genet. https://doi.org/10.1038/s41588-022-01087-y (2022).
Finucane, H. K. et al. Nat. Genet. 47, 1228–1235 (2015).
Mountjoy, E. et al. Nat. Genet. 53, 1527–1533 (2021).
Weissbrod, O. et al. Nat. Genet. 52, 1355–1363 (2020).
Boyle, E. A., Li, Y. I. & Pritchard, J. K. Cell 169, 1177–1186 (2017).
Wray, N. R., Wijmenga, C., Sullivan, P. F., Yang, J. & Visscher, P. M. Cell 173, 1573–1580 (2018).
Backman, J. D. et al. Nature 599, 628–634 (2021).
Nasser, J. et al. Nature 593, 238–243 (2021).
Abell, N. S. et al. Science 375, 1247–1254 (2022).
Perez, R. K. et al. Science 376, eabf1970 (2022).
Yazar, S. et al. Science 376, eabf3041 (2022).
Musunuru, K. et al. Nature 466, 714–719 (2010).
Bauer, D. E. et al. Science 342, 253–257 (2013).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing interests.
Rights and permissions
About this article
Cite this article
Lettre, G. One step closer to linking GWAS SNPs with the right genes. Nat Genet 54, 748–749 (2022). https://doi.org/10.1038/s41588-022-01093-0
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41588-022-01093-0
This article is cited by
-
eQTL colocalization analysis highlights novel susceptibility genes in Autism Spectrum Disorders (ASD)
Translational Psychiatry (2023)