Oncogene amplification is a major driver of tumorigenesis; yet, the mechanisms generating amplification are only partially understood. New research reports on the identification of a new focal amplification pattern termed ‘seismic amplification’ that is hypothesized to originate from recombination between extrachromosomal DNA circles.
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Pellman, D., Zhang, CZ. Decoding complex patterns of oncogene amplification. Nat Genet 53, 1626–1627 (2021). https://doi.org/10.1038/s41588-021-00974-0
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DOI: https://doi.org/10.1038/s41588-021-00974-0
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Extrachromosomal circular DNA: biogenesis, structure, functions and diseases
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