We developed synthetic serum markers that can be expressed in the brain but are transported into the blood, enabling minimally invasive monitoring of gene expression in the brain with a simple blood test.
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References
Alfaro, J. A. et al. The emerging landscape of single-molecule protein sequencing technologies. Nat. Methods 18, 604–617 (2021). This review presents technologies for single-molecule protein sequencing.
Zhang, Y. & Pardridge, W. M. Mediated efflux of IgG molecules from brain to blood across the blood–brain barrier. J. Neuroimmunol. 114, 168–172 (2001). This paper reports the discovery of reverse transcytosis of antibodies from the brain into the blood.
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This is a summary of: Lee, S. et al. Engineered serum markers for non-invasive monitoring of gene expression in the brain. Nat. Biotechnol. https://doi.org/10.1038/s41587-023-02087-x (2024).
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Monitoring gene expression in the brain with a blood test. Nat Biotechnol (2024). https://doi.org/10.1038/s41587-023-02088-w
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DOI: https://doi.org/10.1038/s41587-023-02088-w
