Genetically encoded concentric barcodes function as multiplexed electron microscopy (EM) gene reporters (EMcapsulins) for cell culture and in vivo models. These barcodes can be used to visualize gene expression information as automatically labeled overlays on volume EM data.
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This is a summary of: Sigmund, F. et al. Genetically encoded barcodes for correlative volume electron microscopy. Nat. Biotechnol. https://doi.org/10.1038/s41587-023-01713-y (2023).
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Augmenting electron microscopy with barcoded gene reporters. Nat Biotechnol 41, 1692–1693 (2023). https://doi.org/10.1038/s41587-023-01731-w
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DOI: https://doi.org/10.1038/s41587-023-01731-w
