Using a combination of metagenomic big data and deep learning tools, small proteins that inhibit pathogens — and could be further developed into novel antibiotics — are mined en masse. Such methods could greatly improve the throughput of drug discovery and translational usage of the microbiome.
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This is a summary of: Ma, Y. et al. Identification of antimicrobial peptides from the human gut microbiome using deep learning. Nat. Biotechnol. https://doi.org/10.1038/s41587-022-01226-0 (2022).
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Identification of antimicrobial peptides from the human gut microbiome using deep learning. Nat Biotechnol 40, 838–839 (2022). https://doi.org/10.1038/s41587-022-01230-4
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DOI: https://doi.org/10.1038/s41587-022-01230-4
