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Understanding and managing the cardiovascular risks of androgen deprivation therapy for prostate cancer

Nature Reviews Urology volume 20, pages 3–4 (2023)Cite this article

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Androgen deprivation therapy potentiates cardiovascular morbidity and mortality, which is the most common cause of non-cancer-related death in patients with prostate cancer. Whether the mode of testosterone suppression affects the risk of cardiovascular adverse events is unclear, especially as the 2021 PRONOUNCE trial — which aimed to compare the cardiovascular risks of gonadotropin-releasing hormone (GnRH) antagonists with GnRH agonists — was prematurely terminated.

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Authors and Affiliations

  1. Department of Urology, Barts Health NHS Trust, Whipps Cross University Hospital, London, UK

    Kerem Atalar

  2. Barts Cancer Institute, Queen Mary University of London, London, UK

    Prabhakar Rajan

  3. Department of Urology, Barts Health NHS Trust, The Royal London Hospital, London, UK

    Prabhakar Rajan

Authors
  1. Kerem Atalar
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  2. Prabhakar Rajan
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Corresponding author

Correspondence to Kerem Atalar.

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Competing interests

P.R. declares research grant support from Ferring Pharmaceuticals. K.A. declares no competing interests.

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Atalar, K., Rajan, P. Understanding and managing the cardiovascular risks of androgen deprivation therapy for prostate cancer. Nat Rev Urol 20, 3–4 (2023). https://doi.org/10.1038/s41585-022-00671-5

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