Cancer care is currently experiencing rapid development in novel therapeutics, with an associated rise in treatment costs. These changes not only create a critical challenge for therapeutic decision-making but also highlight the need to prioritize therapies of high clinical and economic value. Health technology assessment methodology is a novel approach that could help guide value-based decision-making.
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References
Cherny, N. I. et al. A standardised, generic, validated approach to stratify the magnitude of clinical benefit that can be anticipated from anti-cancer therapies: the European Society for Medical Oncology Magnitude of Clinical Benefit Scale (ESMO-MCBS). Ann. Oncol. 26, 1547–1573 (2015).
Schnipper, L. E. et al. American Society of Clinical Oncology statement: a conceptual framework to assess the value of cancer treatment options. J. Clin. Oncol. 33, 2563–2577 (2015).
National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology (NCCN Guidelines) with NCCN evidence blocks. NCCN https://www.nccn.org/evidenceblocks (2018).
Banta, D. What is technology assessment? Int. J. Technol. Assess. Health Care 25 (Suppl. 1), 7–9 (2009).
Goodman, C. S. HTA 101: introduction to health technology assessment. NIH https://www.nlm.nih.gov/nichsr/hta101/HTA_101_FINAL_7-23-14.pdf (2014).
National Institute for Health and Care Excellence. Guide to the methods of technology appraisal 2013. NICE https://www.nice.org.uk/process/pmg9/resources/guide-to-the-methods-of-technology-appraisal-2013-pdf-2007975843781 (2013).
Lalani, A. A. et al. Systemic treatment of metastatic clear cell renal cell carcinoma in 2018: current paradigms, use of immunotherapy, and future directions. Eur. Urol. 75, 100–110 (2019).
Motzer, R. J. et al. Nivolumab plus ipilimumab versus sunitinib in advanced renal-cell carcinoma. N. Engl. J. Med. 378, 1277–1290 (2018).
Rini, B. I. et al. Pembrolizumab plus axitinib versus sunitinib for advanced renal-cell carcinoma. N. Engl. J. Med. 380, 1116–1127 (2019).
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Parmar, A., Chan, K.K.W. Health technology assessment methodology in metastatic renal cell carcinoma. Nat Rev Urol 17, 3–5 (2020). https://doi.org/10.1038/s41585-019-0257-4
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DOI: https://doi.org/10.1038/s41585-019-0257-4
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