A substantial percentage of patients with inflammatory bowel disease (IBD) exhibit biologic treatment failure or loss of response over time. This article explores the effectiveness and safety of monoclonal antibodies targeting the IL-23 pathway in treating IBD; continued research is needed to address lingering questions regarding long-term safety and efficacy.
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References
Danese, S. New therapies for inflammatory bowel disease: from the bench to the bedside. Gut 61, 918–932 (2012).
Almradi, A. et al. Clinical trials of IL-12/IL-23 inhibitors in inflammatory bowel disease. BioDrugs 34, 713–721 (2020).
Danese, S., Vuitton, L. & Peyrin-Biroulet, L. Biologic agents for IBD: practical insights. Nat. Rev. Gastroenterol. Hepatol. 12, 537–545 (2015).
Roda, G., Jharap, B., Neeraj, N. & Colombel, J.-F. Loss of response to anti-TNFs: definition, epidemiology, and management. Clin. Transl Gastroenterol. 7, e135 (2016).
Hanžel, J. & D’Haens, G. R. Anti-interleukin-23 agents for the treatment of ulcerative colitis. Expert Opin. Biol. Ther. 20, 399–406 (2020).
Parigi, T. L., Iacucci, M. & Ghosh, S. Blockade of IL-23: what is in the pipeline? J. Crohns Colitis 16 (Suppl. 2), ii64–ii72 (2022).
Noviello, D. et al. The IL23-IL17 immune axis in the treatment of ulcerative colitis: successes, defeats, and ongoing challenges. Front. Immunol. 12, 611256 (2021).
Verstockt, B. et al. IL-12 and IL-23 pathway inhibition in inflammatory bowel disease. Nat. Rev. Gastroenterol. Hepatol. 20, 433–446 (2023).
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S.D. has served as a speaker, consultant and advisory board member for Schering Plough, Abbott (AbbVie) Laboratories, Merck and Co, UCB Pharma, Ferring, Cellerix, Millenium Takeda, Nycomed, Pharmacosmos, Actelion, Alfa Wasserman, Genentech, Grunenthal, Pfizer, AstraZeneca, Novo Nordisk, Vifor and Johnson and Johnson. L.P.-B. has served as consultant for Merck, AbbVie, Janssen, Genentech, Ferring, Tillots, Vifor, Pharmacosmos, Celltrion, Takeda, Biogaran, Boehringer-Ingelheim, Lilly, Pfizer, Jndex Pharmaceuticals, Amgen, Sandoz, Celgene, Biogen, Samsung Bioepis, Alma, Sterna, Nestlé, Enterome, Mylan, HAC-Pharma and Tigenix, and has served as speaker for Merck, AbbVie, Janssen, Genentech, Ferring, Tillots, Vifor, Pharmacosmos, Celltrion, Takeda, Boehringer-Ingelheim, Pfizer, Amgen, Biogen and Samsung Bioepis.
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NCT03466411: https://clinicaltrials.gov/study/NCT03466411
NCT03926130: https://clinicaltrials.gov/study/NCT03926130
NCT04524611: https://www.clinicaltrials.gov/study/NCT04524611
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Danese, S., Peyrin-Biroulet, L. Are all the IL-23 blockers the same in inflammatory bowel disease?. Nat Rev Gastroenterol Hepatol 21, 138–139 (2024). https://doi.org/10.1038/s41575-023-00889-7
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DOI: https://doi.org/10.1038/s41575-023-00889-7
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